| Decheng Capital LLC | 3,917,299 | $22.6m | 3.1% |
| CITADEL ADVISORS LLC | 1,283,166 | $7.4m | 0.0% |
| Laurion Capital Management LP | 1,034,459 | $6.0m | 0.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 562,877 | $3.2m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 480,249 | $2.8m | 0.0% |
| EcoR1 Capital, LLC | 396,194 | $2.3m | 0.1% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 300,000 | $1.7m | 0.0% |
| CANTOR FITZGERALD, L. P. | 233,164 | $1.3m | 0.0% |
| BlackRock, Inc. | 187,045 | $1.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 149,844 | $863,529 | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 108,377 | $624,252 | 0.0% |
| RAYMOND JAMES FINANCIAL INC | 79,284 | $456,676 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 75,172 | $432,991 | 0.0% |
| Woodline Partners LP | 72,429 | $417,191 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 69,948 | $402,900 | 0.0% |
| STATE STREET CORP | 59,273 | $341,412 | 0.0% |
| J. Goldman & Co LP | 40,500 | $233,280 | 0.0% |
| IEQ CAPITAL, LLC | 38,382 | $221,080 | 0.0% |
| UBS Group AG | 35,639 | $205,281 | 0.0% |
| MORGAN STANLEY | 30,177 | $173,820 | 0.0% |
| NORTHERN TRUST CORP | 28,080 | $161,741 | 0.0% |
| CITIGROUP INC | 26,299 | $151,482 | 0.0% |
| Cresset Asset Management, LLC | 24,033 | $138,430 | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,025 | $138,384 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 24,000 | $138,240 | 0.0% |