| RA CAPITAL MANAGEMENT, L.P. | 932,624 | $8.1m | 0.1% |
| ORBIMED ADVISORS LLC | 844,787 | $7.3m | 0.1% |
| FRANKLIN RESOURCES INC | 626,571 | $5.4m | 0.0% |
| CITADEL ADVISORS LLC | 432,738 | $3.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 343,228 | $3.0m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 274,375 | $2.4m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 265,945 | $2.3m | 0.0% |
| Stonepine Capital Management, LLC | 245,518 | $2.1m | 0.5% |
| Alyeska Investment Group, L.P. | 203,799 | $1.8m | 0.0% |
| Schonfeld Strategic Advisors LLC | 195,514 | $1.7m | 0.0% |
| Carlyle Group Inc. | 184,295 | $1.6m | 0.0% |
| NEXTBio Capital Management LP | 157,827 | $1.4m | 0.6% |
| ACADIAN ASSET MANAGEMENT LLC | 124,832 | $1.1m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 96,839 | $836,689 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 95,634 | $826,703 | 0.0% |
| DAFNA Capital Management LLC | 93,812 | $810,536 | 0.2% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85,959 | $742,686 | 0.0% |
| MARSHALL WACE, LLP | 79,488 | $686,775 | 0.0% |
| Trexquant Investment LP | 78,002 | $673,937 | 0.0% |
| JANE STREET GROUP, LLC | 70,561 | $609,647 | 0.0% |
| Burkehill Global Management, LP | 62,500 | $540,000 | 0.0% |
| BlackRock, Inc. | 62,126 | $536,769 | 0.0% |
| REGENERON PHARMACEUTICALS, INC. | 60,511 | $522,819 | 0.3% |
| Rangeley Capital, LLC | 50,892 | $439,707 | 0.4% |
| VANGUARD FIDUCIARY TRUST CO | 50,670 | $437,789 | 0.0% |