| Frazier Life Sciences Management, L.P. | 7,614,836 | $49.7m | 1.1% |
| TPG GP A, LLC | 6,877,580 | $44.9m | 0.9% |
| venBio Partners LLC | 5,914,720 | $38.6m | 7.4% |
| Logos Global Management LP | 5,425,000 | $35.4m | 1.5% |
| BlackRock, Inc. | 5,272,017 | $34.4m | 0.0% |
| FRANKLIN RESOURCES INC | 4,953,220 | $32.3m | 0.0% |
| Paradigm Biocapital Advisors LP | 4,951,856 | $32.3m | 0.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,140,812 | $27.0m | 0.0% |
| Propel Bio Management, LLC | 4,034,018 | $26.3m | 13.8% |
| MARSHALL WACE, LLP | 3,770,313 | $24.6m | 0.0% |
| STATE STREET CORP | 2,945,526 | $19.2m | 0.0% |
| Venrock Adviser, LLC | 2,751,032 | $18.0m | 0.5% |
| Vivo Capital, LLC | 2,751,032 | $18.0m | 1.6% |
| Jupiter Topco LLC | 2,751,032 | $18.0m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,220,000 | $14.5m | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,062,721 | $13.5m | 0.0% |
| Alyeska Investment Group, L.P. | 1,925,722 | $12.6m | 0.0% |
| Simplify Asset Management Inc. | 1,432,105 | $9.4m | 0.1% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,426,915 | $9.3m | 0.0% |
| LPL Financial LLC | 902,255 | $5.9m | 0.0% |
| NORTHERN TRUST CORP | 743,760 | $4.9m | 0.0% |
| Spruce Street Capital LP | 736,637 | $4.8m | 0.9% |
| VANGUARD FIDUCIARY TRUST CO | 593,751 | $3.9m | 0.0% |
| RAYMOND JAMES FINANCIAL INC | 546,318 | $3.6m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 537,596 | $3.5m | 0.0% |