| Opaleye Management Inc. | 2,895,467 | $20.9m | 1.9% |
| Solas Capital Management, LLC | 1,924,617 | $13.9m | 7.4% |
| AWM Investment Company, Inc. | 1,672,168 | $12.1m | 1.0% |
| Cable Car Capital, LP | 1,382,339 | $10.0m | 0.2% |
| Ikarian Capital, LLC | 836,259 | $6.0m | 0.7% |
| SPHERA FUNDS MANAGEMENT LTD. | 545,816 | $3.9m | 0.5% |
| Alyeska Investment Group, L.P. | 365,000 | $2.6m | 0.0% |
| Aristides Capital LLC | 218,510 | $1.6m | 0.3% |
| CANTOR FITZGERALD, L. P. | 217,836 | $1.6m | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 189,148 | $1.4m | 0.0% |
| CITADEL ADVISORS LLC | 97,546 | $704,282 | 0.0% |
| VILLERE ST DENIS J & CO LLC | 71,158 | $513,760 | 0.1% |
| TUDOR INVESTMENT CORP ET AL | 61,596 | $444,723 | 0.0% |
| ACT CAPITAL MANAGEMENT, LLC | 51,500 | $371,830 | 0.2% |
| BERKSHIRE ASSET MANAGEMENT LLC/PA | 19,824 | $143,129 | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 18,832 | $135,967 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 11,992 | $86,582 | 0.0% |
| RAYMOND JAMES FINANCIAL INC | 10,000 | $72,200 | 0.0% |
| NATIONAL BANK OF CANADA /FI/ | 5,292 | $37,717 | 0.0% |
| UBS Group AG | 1,456 | $10,512 | 0.0% |
| Allworth Financial LP | 750 | $5,415 | 0.0% |
| JONES FINANCIAL COMPANIES LLLP | 250 | $1,625 | 0.0% |
| Steward Partners Investment Advisory, LLC | 200 | $1,444 | 0.0% |
| MORGAN STANLEY | 200 | $1,444 | 0.0% |
| ROYAL BANK OF CANADA | 122 | $1,000 | 0.0% |