| RA CAPITAL MANAGEMENT, L.P. | 12,723,026 | $67.3m | 0.6% |
| BML Capital Management, LLC | 11,975,000 | $63.3m | 36.0% |
| BlackRock, Inc. | 10,037,008 | $53.1m | 0.0% |
| Deep Track Capital, LP | 9,345,000 | $49.4m | 0.7% |
| Vivo Capital, LLC | 6,694,637 | $35.4m | 3.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 5,817,866 | $30.8m | 0.0% |
| Frazier Life Sciences Management, L.P. | 4,925,374 | $26.1m | 0.6% |
| Rock Springs Capital Management LP | 4,330,532 | $22.9m | 1.1% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,071,000 | $21.5m | 0.0% |
| Decheng Capital LLC | 4,041,736 | $21.4m | 2.9% |
| Kalehua Capital Management LLC | 3,664,730 | $19.4m | 6.2% |
| STATE STREET CORP | 3,255,340 | $17.2m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,190,058 | $16.9m | 0.0% |
| BRAIDWELL LP | 2,142,348 | $11.3m | 0.4% |
| Balyasny Asset Management L.P. | 2,023,470 | $10.7m | 0.0% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,946,482 | $10.3m | 1.1% |
| CITADEL ADVISORS LLC | 1,762,081 | $9.3m | 0.0% |
| Jones Hill Capital LP | 1,759,492 | $9.3m | 2.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,641,472 | $8.7m | 0.0% |
| Palo Alto Investors LP | 1,613,430 | $8.5m | 1.2% |
| Woodline Partners LP | 1,611,054 | $8.5m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,465,735 | $7.8m | 0.0% |
| PANAGORA ASSET MANAGEMENT INC | 1,356,152 | $7.2m | 0.0% |
| Connor, Clark & Lunn Investment Management Ltd. | 1,209,886 | $6.4m | 0.0% |
| MPM BIOIMPACT LLC | 1,042,467 | $5.5m | 0.3% |