| RA CAPITAL MANAGEMENT, L.P. | 12,229,396 | $21.8m | 0.2% |
| Sands Capital Alternatives, LLC | 2,289,271 | $4.1m | 0.7% |
| ACADIAN ASSET MANAGEMENT LLC | 1,165,119 | $2.1m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 952,008 | $1.7m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 888,130 | $1.6m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 758,863 | $1.4m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 641,498 | $1.1m | 0.0% |
| MARSHALL WACE, LLP | 531,856 | $946,704 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 378,900 | $674,442 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 265,241 | $472,273 | 0.0% |
| BlackRock, Inc. | 239,112 | $425,620 | 0.0% |
| GSA CAPITAL PARTNERS LLP | 200,415 | $357,000 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 184,128 | $327,748 | 0.0% |
| XTX Topco Ltd | 178,239 | $317,265 | 0.0% |
| JANE STREET GROUP, LLC | 74,648 | $132,874 | 0.0% |
| NORTHERN TRUST CORP | 67,202 | $119,620 | 0.0% |
| STATE STREET CORP | 67,145 | $119,518 | 0.0% |
| UBS Group AG | 43,850 | $78,053 | 0.0% |
| CITADEL ADVISORS LLC | 41,276 | $73,471 | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 29,332 | $52,212 | 0.0% |
| Spark Investment Management LLC | 28,300 | $50,374 | 0.1% |
| PRELUDE CAPITAL MANAGEMENT, LLC | 24,015 | $42,747 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 16,407 | $29,204 | 0.0% |
| Verdad Advisers, LP | 15,054 | $26,796 | 0.0% |
| GOLDMAN SACHS GROUP INC | 14,920 | $26,558 | 0.0% |