| BlackRock, Inc. | 38,355,684 | $321.0m | 0.0% |
| STATE STREET CORP | 17,116,022 | $143.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 10,103,809 | $84.6m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 10,088,490 | $84.4m | 0.0% |
| Rubric Capital Management LP | 9,339,414 | $78.2m | 0.7% |
| Capital Research Global Investors | 8,756,374 | $73.3m | 0.0% |
| FIRST TRUST ADVISORS LP | 7,798,351 | $65.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 6,059,984 | $50.7m | 0.0% |
| Caligan Partners LP | 5,725,007 | $47.9m | 2.3% |
| D. E. Shaw & Co., Inc. | 5,274,597 | $44.1m | 0.0% |
| Nantahala Capital Management, LLC | 4,719,986 | $39.5m | 0.7% |
| DIMENSIONAL FUND ADVISORS LP | 3,606,208 | $30.2m | 0.0% |
| GOLDMAN SACHS GROUP INC | 3,513,583 | $29.4m | 0.0% |
| B Group, Inc. | 3,262,542 | $27.3m | 12.8% |
| Nuveen, LLC | 3,260,349 | $27.3m | 0.0% |
| Duquesne Family Office LLC | 2,784,110 | $23.3m | 0.4% |
| NORTHERN TRUST CORP | 2,415,971 | $20.2m | 0.0% |
| MORGAN STANLEY | 2,265,443 | $19.0m | 0.0% |
| Ranger Investment Management, L.P. | 2,115,417 | $17.7m | 1.1% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,092,594 | $17.5m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,019,887 | $16.9m | 0.0% |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,755,152 | $14.7m | 0.3% |
| VANGUARD FIDUCIARY TRUST CO | 1,654,613 | $13.8m | 0.0% |
| Fundsmith LLP | 1,649,493 | $13.8m | 0.1% |
| BANK OF AMERICA CORP /DE/ | 1,647,647 | $13.8m | 0.0% |