| MPM BIOIMPACT LLC | 4,835,872 | $155.9m | 9.5% |
| EcoR1 Capital, LLC | 4,824,469 | $155.5m | 7.6% |
| Blue Owl Capital Holdings LP | 3,070,219 | $99.0m | 14.9% |
| BlackRock, Inc. | 2,278,358 | $73.4m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 2,051,447 | $66.1m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,966,244 | $63.4m | 0.0% |
| RTW INVESTMENTS, LP | 1,592,043 | $51.3m | 0.4% |
| RA CAPITAL MANAGEMENT, L.P. | 1,314,405 | $42.4m | 0.4% |
| Jupiter Topco LLC | 1,314,267 | $42.4m | 0.0% |
| BAKER BROS. ADVISORS LP | 996,351 | $32.1m | 0.2% |
| Octagon Capital Advisors LP | 960,847 | $31.0m | 2.8% |
| Merck & Co., Inc. | 952,844 | $30.7m | 5.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 817,075 | $26.3m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 763,499 | $24.6m | 0.0% |
| TCG Crossover Management, LLC | 696,560 | $22.5m | 0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 520,737 | $16.8m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 507,000 | $16.3m | 0.2% |
| Avidity Partners Management LP | 484,200 | $15.6m | 2.5% |
| STATE STREET CORP | 484,010 | $15.6m | 0.0% |
| a16z Capital Management, L.L.C. | 415,000 | $13.4m | 0.1% |
| Alyeska Investment Group, L.P. | 290,000 | $9.3m | 0.0% |
| FMR LLC | 285,631 | $9.2m | 0.0% |
| ArrowMark Colorado Holdings LLC | 245,872 | $7.9m | 0.3% |
| NORTHERN TRUST CORP | 180,575 | $5.8m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 166,842 | $5.4m | 0.0% |