| Sands Capital Alternatives, LLC | 4,230,926 | $114.6m | 18.7% |
| SAMSARA BIOCAPITAL, LLC | 2,480,310 | $67.2m | 5.5% |
| T. Rowe Price Investment Management, Inc. | 2,202,597 | $59.7m | 0.0% |
| ARK Investment Management LLC | 1,373,959 | $37.2m | 0.2% |
| BRAIDWELL LP | 1,083,983 | $29.4m | 1.1% |
| ALLIANCEBERNSTEIN L.P. | 1,003,077 | $27.2m | 0.0% |
| HHLR ADVISORS, LTD. | 956,462 | $25.9m | 3.1% |
| BlackRock, Inc. | 911,445 | $24.7m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 865,764 | $23.5m | 0.0% |
| FMR LLC | 829,424 | $22.5m | 0.0% |
| PURA VIDA INVESTMENTS, LLC | 755,909 | $20.5m | 55.4% |
| EMERALD ADVISERS, LLC | 647,183 | $17.5m | 0.4% |
| Artisan Partners Limited Partnership | 613,744 | $16.6m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 600,000 | $16.3m | 0.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 463,385 | $12.6m | 0.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 462,900 | $12.5m | 0.1% |
| WELLINGTON MANAGEMENT GROUP LLP | 457,974 | $12.4m | 0.0% |
| EMERALD MUTUAL FUND ADVISERS TRUST | 422,127 | $11.4m | 0.4% |
| AMERIPRISE FINANCIAL INC | 418,965 | $11.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 330,134 | $8.9m | 0.0% |
| Woodline Partners LP | 243,320 | $6.6m | 0.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 200,758 | $5.4m | 0.0% |
| CITADEL ADVISORS LLC | 180,000 | $4.9m | 0.0% |
| LORD, ABBETT & CO. LLC | 177,552 | $4.8m | 0.0% |
| LMR Partners LLP | 175,000 | $4.7m | 0.0% |