| Cormorant Asset Management, LP | 3,978,229 | $45.7m | 2.3% |
| Venrock Adviser, LLC | 3,212,731 | $36.9m | 1.1% |
| Balyasny Asset Management L.P. | 3,061,668 | $35.2m | 0.0% |
| Point72 Asset Management, L.P. | 2,140,664 | $24.6m | 0.0% |
| MPM BIOIMPACT LLC | 1,936,291 | $22.3m | 1.4% |
| PERCEPTIVE ADVISORS LLC | 1,793,190 | $20.6m | 0.3% |
| Casdin Capital, LLC | 1,250,000 | $14.4m | 0.7% |
| ADAR1 Capital Management, LLC | 1,017,805 | $11.7m | 0.5% |
| Octagon Capital Advisors LP | 934,716 | $10.7m | 1.0% |
| MILLENNIUM MANAGEMENT LLC | 807,832 | $9.3m | 0.0% |
| BRAIDWELL LP | 795,214 | $9.1m | 0.3% |
| Squadron Capital Management LLC | 764,876 | $8.8m | 2.7% |
| EVENTIDE ASSET MANAGEMENT, LLC | 718,747 | $8.3m | 0.1% |
| SUPERSTRING CAPITAL MANAGEMENT LP | 552,501 | $6.4m | 4.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 538,461 | $6.2m | 0.0% |
| Woodline Partners LP | 455,733 | $5.2m | 0.0% |
| Soleus Capital Management, L.P. | 405,523 | $4.7m | 0.2% |
| Freestone Grove Partners LP | 397,446 | $4.6m | 0.0% |
| BOONE CAPITAL MANAGEMENT LLC | 258,390 | $3.0m | 0.7% |
| DAFNA Capital Management LLC | 239,553 | $2.8m | 0.5% |
| Kalehua Capital Management LLC | 226,415 | $2.6m | 0.8% |
| Affinity Asset Advisors, LLC | 153,847 | $1.8m | 0.1% |
| Seven Fleet Capital Management LP | 113,207 | $1.3m | 0.2% |
| DV Trading LLC | 113,207 | $1.3m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 94,100 | $1.1m | 0.0% |