| Vivo Capital, LLC | 3,153,640 | $15.3m | 1.4% |
| Commodore Capital LP | 2,933,680 | $14.2m | 0.8% |
| MILLENNIUM MANAGEMENT LLC | 2,318,692 | $11.2m | 0.0% |
| BlackRock, Inc. | 1,665,494 | $8.1m | 0.0% |
| Spruce Street Capital LP | 1,661,073 | $8.0m | 1.6% |
| Almitas Capital LLC | 1,469,129 | $7.1m | 1.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,238,705 | $6.0m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,000,000 | $4.8m | 0.0% |
| CITADEL ADVISORS LLC | 951,997 | $4.6m | 0.0% |
| Boxer Capital Management, LLC | 749,035 | $3.6m | 0.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 697,806 | $3.4m | 0.0% |
| SummitTX Capital, L.P. | 597,453 | $2.9m | 0.1% |
| Balyasny Asset Management L.P. | 556,027 | $2.7m | 0.0% |
| Stonepine Capital Management, LLC | 551,692 | $2.7m | 0.7% |
| AMERIPRISE FINANCIAL INC | 537,064 | $2.6m | 0.0% |
| Sio Capital Management, LLC | 529,933 | $2.6m | 0.4% |
| Ally Bridge Group (NY) LLC | 526,315 | $2.5m | 2.3% |
| Prosight Management, LP | 474,638 | $2.3m | 0.4% |
| Woodline Partners LP | 459,805 | $2.2m | 0.0% |
| STATE STREET CORP | 311,602 | $1.5m | 0.0% |
| NORTHERN TRUST CORP | 214,921 | $1.0m | 0.0% |
| Seven Fleet Capital Management LP | 208,946 | $1.0m | 0.2% |
| VANGUARD FIDUCIARY TRUST CO | 196,920 | $953,093 | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 179,594 | $869,235 | 0.0% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 167,446 | $810,438 | 0.1% |