| RA CAPITAL MANAGEMENT, L.P. | 17,955,642 | $174.2m | 1.5% |
| VIKING GLOBAL INVESTORS LP | 2,604,166 | $25.3m | 0.1% |
| Blackstone Inc. | 2,403,437 | $23.3m | 0.1% |
| 5AM Venture Management, LLC | 2,353,304 | $22.8m | 7.9% |
| Venrock Adviser, LLC | 2,043,596 | $19.8m | 0.6% |
| FRANKLIN RESOURCES INC | 1,997,223 | $19.4m | 0.0% |
| Caligan Partners LP | 1,736,111 | $16.8m | 0.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 981,815 | $9.5m | 0.0% |
| SAMSARA BIOCAPITAL, LLC | 954,861 | $9.3m | 0.8% |
| Blue Owl Capital Holdings LP | 874,542 | $8.5m | 1.3% |
| Propel Bio Management, LLC | 696,436 | $6.8m | 3.5% |
| BlackRock, Inc. | 694,726 | $6.7m | 0.0% |
| CITADEL ADVISORS LLC | 609,376 | $5.9m | 0.0% |
| Nantahala Capital Management, LLC | 600,000 | $5.8m | 0.1% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 525,000 | $5.1m | 0.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 353,845 | $3.4m | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 314,375 | $3.0m | 0.0% |
| Revelation Capital Management, LLC | 299,311 | $2.9m | 2.7% |
| Alyeska Investment Group, L.P. | 273,615 | $2.7m | 0.0% |
| ACUTA CAPITAL PARTNERS, LLC | 260,416 | $2.5m | 1.8% |
| KVP Capital Advisors, LP | 200,000 | $1.9m | 1.4% |
| WELLINGTON MANAGEMENT GROUP LLP | 194,108 | $1.9m | 0.0% |
| UBS Group AG | 184,020 | $1.8m | 0.0% |
| SEVEN GRAND MANAGERS, LLC | 175,000 | $1.7m | 0.1% |
| STATE STREET CORP | 165,764 | $1.6m | 0.0% |