| GILEAD SCIENCES, INC. | 4,977,089 | $136.8m | 8.3% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 1,604,590 | $44.1m | 0.2% |
| Paradigm Biocapital Advisors LP | 1,553,748 | $42.7m | 0.8% |
| Commodore Capital LP | 1,415,000 | $38.9m | 2.3% |
| RA CAPITAL MANAGEMENT, L.P. | 1,020,410 | $28.0m | 0.2% |
| Jupiter Topco LLC | 849,309 | $23.4m | 0.0% |
| BlackRock, Inc. | 766,819 | $21.1m | 0.0% |
| Parkman Healthcare Partners LLC | 721,181 | $19.8m | 2.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 558,942 | $15.4m | 0.0% |
| Point72 Asset Management, L.P. | 460,593 | $12.7m | 0.0% |
| Seven Fleet Capital Management LP | 433,147 | $11.9m | 2.0% |
| MILLENNIUM MANAGEMENT LLC | 298,807 | $8.2m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 280,424 | $7.7m | 0.0% |
| Schonfeld Strategic Advisors LLC | 242,153 | $6.7m | 0.0% |
| AMERIPRISE FINANCIAL INC | 230,000 | $6.3m | 0.0% |
| DV EQUITIES, LLC | 226,415 | $6.2m | 0.9% |
| Aberdeen Group plc | 207,047 | $5.7m | 0.0% |
| Affinity Asset Advisors, LLC | 190,000 | $5.2m | 0.2% |
| B Group, Inc. | 175,706 | $4.8m | 2.3% |
| STATE STREET CORP | 171,931 | $4.7m | 0.0% |
| STEMPOINT CAPITAL LP | 170,378 | $4.7m | 0.8% |
| Squadron Capital Management LLC | 160,000 | $4.4m | 1.4% |
| Woodline Partners LP | 150,780 | $4.1m | 0.0% |
| Driehaus Capital Management LLC | 150,000 | $4.1m | 0.0% |
| Ally Bridge Group (NY) LLC | 140,000 | $3.8m | 3.4% |