| FMR LLC | 5,835,259 | $192.1m | 0.0% |
| NOVO HOLDINGS A/S | 3,883,289 | $127.8m | 7.4% |
| SR One Capital Management, LP | 3,308,649 | $108.9m | 10.5% |
| PERCEPTIVE ADVISORS LLC | 2,675,296 | $88.1m | 1.3% |
| MONTANOVA CAPITAL, LLC | 2,503,109 | $82.4m | 1.5% |
| NVP ASSOCIATES, LLC | 2,268,404 | $74.7m | 22.8% |
| WELLINGTON MANAGEMENT GROUP LLP | 2,201,986 | $72.5m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,735,231 | $57.1m | 0.0% |
| Catalio Capital Management, LP | 1,675,830 | $55.2m | 10.4% |
| T. Rowe Price Investment Management, Inc. | 1,602,745 | $52.8m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,375,486 | $45.3m | 0.6% |
| Bellevue Group AG | 1,350,000 | $44.4m | 0.9% |
| BlackRock, Inc. | 977,264 | $32.2m | 0.0% |
| Pivotal bioVenture Partners Investment Advisor LLC | 966,792 | $31.8m | 10.3% |
| CITADEL ADVISORS LLC | 959,098 | $31.6m | 0.0% |
| ANDERA PARTNERS | 929,824 | $30.6m | 14.8% |
| JENNISON ASSOCIATES LLC | 812,749 | $26.8m | 0.0% |
| BRAIDWELL LP | 801,395 | $26.4m | 1.0% |
| TPG GP A, LLC | 773,069 | $25.4m | 0.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 739,770 | $24.4m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 731,000 | $24.1m | 0.3% |
| Rock Springs Capital Management LP | 662,918 | $21.8m | 1.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 434,650 | $14.3m | 0.0% |
| Soleus Capital Management, L.P. | 419,000 | $13.8m | 0.5% |
| INFINITUM ASSET MANAGEMENT, LLC | 411,378 | $13.5m | 1.4% |