| L1 Capital Pty Ltd | 7,789,000 | $76.7m | 2.6% |
| FMR LLC | 6,868,086 | $67.7m | 0.0% |
| Nantahala Capital Management, LLC | 6,766,670 | $66.7m | 1.1% |
| BlackRock, Inc. | 5,771,213 | $56.8m | 0.0% |
| Sio Capital Management, LLC | 5,545,984 | $54.6m | 9.0% |
| PERCEPTIVE ADVISORS LLC | 3,425,476 | $33.7m | 0.5% |
| ADAR1 Capital Management, LLC | 3,145,096 | $31.0m | 1.4% |
| BVF INC/IL | 3,000,000 | $29.6m | 0.8% |
| RA CAPITAL MANAGEMENT, L.P. | 3,000,000 | $29.6m | 0.3% |
| Ensign Peak Advisors, Inc | 2,390,200 | $23.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,102,303 | $20.7m | 0.0% |
| STATE STREET CORP | 1,709,198 | $16.8m | 0.0% |
| Rhenman & Partners Asset Management AB | 1,538,625 | $15.2m | 1.4% |
| Assenagon Asset Management S.A. | 1,289,336 | $12.7m | 0.0% |
| Vestal Point Capital, LP | 1,010,000 | $9.9m | 0.2% |
| Affinity Asset Advisors, LLC | 912,397 | $9.0m | 0.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 879,780 | $8.7m | 0.0% |
| MONTANOVA CAPITAL, LLC | 850,000 | $8.4m | 0.2% |
| UBS Group AG | 752,168 | $7.4m | 0.0% |
| Velan Capital Investment Management LP | 700,000 | $6.9m | 4.2% |
| Militia Capital Management LLC | 670,000 | $6.6m | 0.2% |
| NORTHERN TRUST CORP | 636,088 | $6.3m | 0.0% |
| CITADEL ADVISORS LLC | 610,044 | $6.0m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 548,336 | $5.4m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 451,051 | $4.4m | 0.0% |