| BlackRock, Inc. | 4,419,208 | $204.1m | 0.0% |
| First Light Asset Management, LLC | 2,748,361 | $126.9m | 7.7% |
| MORGAN STANLEY | 2,747,924 | $126.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,257,948 | $104.3m | 0.0% |
| Assenagon Asset Management S.A. | 2,087,300 | $96.4m | 0.1% |
| Polar Capital Holdings Plc | 1,500,822 | $69.3m | 0.2% |
| Artemis Investment Management LLP | 1,396,792 | $64.5m | 0.6% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,391,654 | $64.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,375,240 | $63.5m | 0.0% |
| CITADEL ADVISORS LLC | 1,360,831 | $62.9m | 0.0% |
| WASATCH ADVISORS LP | 1,295,949 | $59.9m | 0.4% |
| GOLDMAN SACHS GROUP INC | 1,261,519 | $58.3m | 0.0% |
| STATE STREET CORP | 1,246,821 | $57.6m | 0.0% |
| FMR LLC | 1,222,864 | $56.5m | 0.0% |
| Hood River Capital Management LLC | 1,067,072 | $49.3m | 0.4% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,018,042 | $47.0m | 0.0% |
| RTW INVESTMENTS, LP | 1,011,576 | $46.7m | 0.4% |
| NEXT CENTURY GROWTH INVESTORS LLC | 872,546 | $40.3m | 2.1% |
| UBS Group AG | 836,209 | $38.6m | 0.0% |
| ARMISTICE CAPITAL, LLC | 775,000 | $35.8m | 0.4% |
| BAMCO INC /NY/ | 740,210 | $34.2m | 0.1% |
| ArrowMark Colorado Holdings LLC | 711,795 | $32.9m | 1.4% |
| Driehaus Capital Management LLC | 707,234 | $32.7m | 0.2% |
| TimesSquare Capital Management, LLC | 689,833 | $31.9m | 0.5% |
| First Eagle Investment Management, LLC | 682,154 | $31.5m | 0.0% |