| BlackRock, Inc. | 8,334,551 | $4.7bn | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 5,130,199 | $2.9bn | 0.1% |
| STATE STREET CORP | 3,885,570 | $2.2bn | 0.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,684,814 | $2.1bn | 0.1% |
| Invesco Ltd. | 3,229,060 | $1.8bn | 0.1% |
| BAILLIE GIFFORD & CO | 3,059,487 | $1.7bn | 1.6% |
| FMR LLC | 3,024,957 | $1.7bn | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,312,765 | $1.3bn | 0.1% |
| WELLINGTON MANAGEMENT GROUP LLP | 2,103,142 | $1.2bn | 0.2% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,871,812 | $1.0bn | 0.1% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,491,490 | $836.1m | 2.7% |
| SANDS CAPITAL MANAGEMENT, LLC | 1,480,817 | $830.2m | 3.1% |
| EDGEWOOD MANAGEMENT LLC | 1,124,675 | $630.5m | 6.5% |
| MORGAN STANLEY | 1,089,164 | $610.6m | 0.0% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,019,560 | $574.1m | 0.2% |
| NORGES BANK | 931,827 | $522.4m | 0.1% |
| UBS Group AG | 927,111 | $519.7m | 0.1% |
| GOLDMAN SACHS GROUP INC | 825,444 | $462.8m | 0.0% |
| NORTHERN TRUST CORP | 774,281 | $434.1m | 0.1% |
| Bank of New York Mellon Corp | 730,899 | $409.7m | 0.1% |
| FRANKLIN RESOURCES INC | 701,731 | $393.4m | 0.1% |
| BROADWOOD CAPITAL INC | 693,504 | $388.8m | 20.3% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 647,298 | $362.9m | 0.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 631,247 | $353.9m | 0.1% |
| Nuveen, LLC | 586,940 | $329.0m | 0.1% |