| BlackRock, Inc. | 23,893,036 | $238.9m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 15,827,186 | $158.3m | 1.4% |
| STATE STREET CORP | 15,191,098 | $151.9m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 15,096,403 | $151.0m | 1.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 11,364,236 | $113.6m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 11,139,158 | $111.4m | 0.0% |
| TCG Crossover Management, LLC | 11,020,968 | $110.2m | 2.6% |
| PERCEPTIVE ADVISORS LLC | 10,308,888 | $103.1m | 1.5% |
| Jupiter Topco LLC | 9,540,764 | $95.3m | 0.0% |
| Vestal Point Capital, LP | 8,300,000 | $83.0m | 1.9% |
| TWO SIGMA INVESTMENTS, LP | 6,775,349 | $67.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 6,248,046 | $62.5m | 0.0% |
| Aberdeen Group plc | 5,310,871 | $53.1m | 0.1% |
| UBS Group AG | 5,078,280 | $50.8m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 4,801,284 | $48.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 4,481,874 | $44.8m | 0.0% |
| Frazier Life Sciences Management, L.P. | 4,009,240 | $40.1m | 0.9% |
| Nuveen, LLC | 4,007,237 | $40.1m | 0.0% |
| Nantahala Capital Management, LLC | 3,802,320 | $38.0m | 0.6% |
| MILLENNIUM MANAGEMENT LLC | 3,394,729 | $33.9m | 0.0% |
| GW&K Investment Management, LLC | 3,171,113 | $31.7m | 0.2% |
| JANE STREET GROUP, LLC | 2,762,683 | $27.6m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 2,718,781 | $27.2m | 0.0% |
| Fisher Asset Management, LLC | 2,604,027 | $26.0m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 2,530,290 | $25.3m | 0.0% |