| AIGH Capital Management LLC | 678,328 | $15.3m | 1.0% |
| Soleus Capital Management, L.P. | 585,958 | $13.2m | 0.5% |
| Telemark Asset Management, LLC | 489,824 | $11.0m | 0.8% |
| Aberdeen Group plc | 388,639 | $8.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 284,169 | $6.4m | 0.0% |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 241,915 | $5.5m | 0.7% |
| Opaleye Management Inc. | 180,000 | $4.1m | 0.4% |
| MARSHALL WACE, LLP | 116,199 | $2.6m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 108,694 | $2.5m | 0.0% |
| JANE STREET GROUP, LLC | 91,506 | $2.1m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 86,824 | $2.0m | 0.0% |
| Legato Capital Management LLC | 81,381 | $1.8m | 0.2% |
| Walleye Capital LLC | 74,447 | $1.7m | 0.0% |
| STEMPOINT CAPITAL LP | 70,000 | $1.6m | 0.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 67,657 | $1.5m | 0.0% |
| Trexquant Investment LP | 57,972 | $1.3m | 0.0% |
| GSA CAPITAL PARTNERS LLP | 46,989 | $1.1m | 0.1% |
| PERKINS CAPITAL MANAGEMENT INC | 44,618 | $1.0m | 0.8% |
| BlackRock, Inc. | 43,026 | $970,236 | 0.0% |
| BLAIR WILLIAM & CO/IL | 41,548 | $936,907 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 39,959 | $901,075 | 0.0% |
| SEI INVESTMENTS CO | 37,295 | $841,002 | 0.0% |
| UBS Group AG | 29,908 | $674,426 | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 28,648 | $646,012 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 26,738 | $602,942 | 0.0% |