| BlackRock, Inc. | 20,445,212 | $1.2bn | 0.0% |
| Dodge & Cox | 14,844,930 | $849.4m | 0.4% |
| PRIMECAP MANAGEMENT CO/CA/ | 14,190,183 | $812.0m | 0.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 8,743,633 | $500.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 8,648,678 | $494.9m | 0.0% |
| NORGES BANK | 8,207,954 | $469.7m | 0.0% |
| STATE STREET CORP | 7,800,959 | $446.4m | 0.0% |
| VIKING GLOBAL INVESTORS LP | 7,616,563 | $435.8m | 1.2% |
| Vestal Point Capital, LP | 6,025,000 | $344.8m | 8.1% |
| AQR CAPITAL MANAGEMENT LLC | 5,699,541 | $322.5m | 0.1% |
| FMR LLC | 4,822,893 | $276.0m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 4,075,714 | $233.2m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,911,794 | $223.9m | 0.0% |
| Assenagon Asset Management S.A. | 3,524,172 | $201.7m | 0.1% |
| Capital Research Global Investors | 3,504,387 | $200.5m | 0.0% |
| Deep Track Capital, LP | 3,307,481 | $189.3m | 2.8% |
| MILLENNIUM MANAGEMENT LLC | 2,071,816 | $118.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,616,020 | $92.5m | 0.0% |
| FIRST TRUST ADVISORS LP | 1,606,273 | $91.9m | 0.1% |
| NORTHERN TRUST CORP | 1,558,104 | $89.2m | 0.0% |
| MORGAN STANLEY | 1,504,989 | $86.1m | 0.0% |
| Jones Hill Capital LP | 1,431,590 | $81.9m | 17.4% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,332,836 | $76.3m | 0.8% |
| Swedbank AB | 1,314,787 | $75.2m | 0.1% |
| UBS Group AG | 1,286,505 | $73.6m | 0.0% |