| FMR LLC | 7,571,805 | $704.6m | 0.0% |
| PRIMECAP MANAGEMENT CO/CA/ | 3,772,031 | $351.0m | 0.2% |
| Dodge & Cox | 3,677,591 | $342.2m | 0.2% |
| FLOSSBACH VON STORCH SE | 2,226,138 | $207.1m | 0.9% |
| T. Rowe Price Investment Management, Inc. | 2,065,456 | $192.2m | 0.1% |
| BlackRock, Inc. | 1,854,966 | $172.6m | 0.0% |
| Temasek Holdings (Private) Ltd | 1,506,027 | $140.1m | 0.4% |
| BNP PARIBAS FINANCIAL MARKETS | 1,319,517 | $122.8m | 0.0% |
| Logos Global Management LP | 1,015,000 | $94.4m | 4.1% |
| GSK plc | 889,824 | $82.8m | 13.7% |
| Assenagon Asset Management S.A. | 846,526 | $78.8m | 0.0% |
| FIRST TRUST ADVISORS LP | 791,469 | $73.6m | 0.0% |
| Davern Capital Partners, LP | 754,550 | $70.2m | 12.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 744,200 | $69.2m | 0.0% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 677,708 | $63.1m | 0.0% |
| Long Focus Capital Management, LLC | 624,000 | $58.1m | 1.5% |
| BAILLIE GIFFORD & CO | 592,380 | $55.1m | 0.1% |
| GOLDMAN SACHS GROUP INC | 589,903 | $54.9m | 0.0% |
| VICTORY CAPITAL MANAGEMENT INC | 539,787 | $50.2m | 0.0% |
| FRANKLIN RESOURCES INC | 539,593 | $50.2m | 0.0% |
| Candriam S.C.A. | 497,530 | $46.3m | 0.2% |
| MORGAN STANLEY | 492,092 | $45.8m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 486,205 | $45.2m | 0.0% |
| TANG CAPITAL MANAGEMENT LLC | 470,000 | $43.7m | 2.0% |
| Balyasny Asset Management L.P. | 463,163 | $43.1m | 0.1% |