| ARCH Venture Management, LLC | 2,694,095 | $6.7m | 0.6% |
| FMR LLC | 2,581,055 | $6.5m | 0.0% |
| TANG CAPITAL MANAGEMENT LLC | 2,559,875 | $6.4m | 0.3% |
| ADAR1 Capital Management, LLC | 1,968,216 | $4.9m | 0.2% |
| Cormorant Asset Management, LP | 1,000,000 | $2.5m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 614,923 | $1.5m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 556,233 | $1.4m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 478,639 | $1.2m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 471,570 | $1.2m | 0.0% |
| Alyeska Investment Group, L.P. | 300,000 | $750,000 | 0.0% |
| Affinity Asset Advisors, LLC | 250,000 | $625,000 | 0.0% |
| RBF Capital, LLC | 200,000 | $500,000 | 0.0% |
| Ensign Peak Advisors, Inc | 159,835 | $399,588 | 0.0% |
| Stonepine Capital Management, LLC | 154,595 | $386,488 | 0.1% |
| ACADIAN ASSET MANAGEMENT LLC | 146,757 | $365,000 | 0.0% |
| CITADEL ADVISORS LLC | 145,049 | $362,623 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 128,000 | $320,000 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 116,736 | $291,839 | 0.0% |
| HRT FINANCIAL LP | 116,288 | $290,000 | 0.0% |
| BlackRock, Inc. | 88,495 | $221,239 | 0.0% |
| PRELUDE CAPITAL MANAGEMENT, LLC | 83,998 | $209,995 | 0.0% |
| Rangeley Capital, LLC | 74,000 | $185,000 | 0.2% |
| GSA CAPITAL PARTNERS LLP | 72,353 | $181,000 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 65,136 | $162,840 | 0.0% |
| JANE STREET GROUP, LLC | 64,323 | $160,807 | 0.0% |