| Jupiter Topco LLC | 6,307,636 | $27.6m | 0.0% |
| 5AM Venture Management, LLC | 5,869,091 | $25.6m | 8.9% |
| FMR LLC | 4,904,339 | $21.4m | 0.0% |
| Vivo Capital, LLC | 4,246,568 | $18.6m | 1.7% |
| Balyasny Asset Management L.P. | 2,575,724 | $11.3m | 0.0% |
| a16z Capital Management, L.L.C. | 2,125,339 | $9.3m | 0.1% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,960,784 | $8.6m | 0.0% |
| Trails Edge Capital Partners, LP | 1,932,937 | $8.4m | 1.3% |
| BlackRock, Inc. | 1,644,134 | $7.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,533,489 | $6.7m | 0.0% |
| ENAVATE SCIENCES GP, LLC | 1,425,541 | $6.2m | 1.8% |
| Stonepine Capital Management, LLC | 1,389,622 | $6.1m | 1.6% |
| HarbourVest Partners LLC | 1,271,948 | $5.6m | 3.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 795,651 | $3.5m | 0.0% |
| SummitTX Capital, L.P. | 725,160 | $3.2m | 0.1% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 653,594 | $2.9m | 0.3% |
| STATE STREET CORP | 362,300 | $1.6m | 0.0% |
| NORTHERN TRUST CORP | 248,673 | $1.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 241,393 | $1.1m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 226,074 | $987,943 | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 220,717 | $964,533 | 0.0% |
| Birchview Capital, LP | 120,000 | $524,400 | 0.2% |
| CANTOR FITZGERALD, L. P. | 107,000 | $467,590 | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 104,610 | $457,146 | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 96,660 | $422,404 | 0.0% |