| BlackRock, Inc. | 9,645,932 | $757.0m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 6,642,936 | $537.4m | 0.2% |
| Artal Group S.A. | 6,507,990 | $510.7m | 54.9% |
| FMR LLC | 5,528,752 | $433.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,486,095 | $352.1m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,213,225 | $330.7m | 0.0% |
| STATE STREET CORP | 3,098,230 | $243.2m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,034,360 | $238.1m | 0.0% |
| 1832 Asset Management L.P. | 2,525,500 | $198.2m | 0.1% |
| MORGAN STANLEY | 2,127,156 | $166.9m | 0.0% |
| Capital International Investors | 2,058,240 | $161.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,003,627 | $157.3m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,605,508 | $126.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,515,184 | $118.9m | 0.0% |
| AMERIPRISE FINANCIAL INC | 1,473,206 | $115.6m | 0.0% |
| Capital Research Global Investors | 1,444,258 | $113.4m | 0.0% |
| Clearbridge Investments, LLC | 1,406,266 | $110.4m | 0.1% |
| Hood River Capital Management LLC | 1,406,249 | $110.4m | 0.8% |
| NORGES BANK | 1,328,728 | $104.3m | 0.0% |
| CITIGROUP INC | 1,244,918 | $97.7m | 0.0% |
| JANE STREET GROUP, LLC | 1,241,232 | $97.4m | 0.0% |
| PRIMECAP MANAGEMENT CO/CA/ | 1,184,450 | $93.0m | 0.1% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,145,019 | $89.9m | 0.3% |
| TWO SIGMA INVESTMENTS, LP | 1,139,942 | $89.5m | 0.1% |
| Prime Capital Management Co Ltd | 1,031,630 | $81.0m | 6.5% |