| BlackRock, Inc. | 7,284,352 | $16.5m | 0.0% |
| Nantahala Capital Management, LLC | 7,247,226 | $16.4m | 0.3% |
| Opaleye Management Inc. | 6,785,000 | $15.3m | 1.4% |
| Aberdeen Group plc | 6,769,954 | $15.3m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 5,549,139 | $12.5m | 0.0% |
| Telemark Asset Management, LLC | 3,846,411 | $8.7m | 0.6% |
| AMERIPRISE FINANCIAL INC | 3,809,440 | $8.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,617,109 | $8.2m | 0.0% |
| Assenagon Asset Management S.A. | 2,556,412 | $5.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,162,393 | $4.9m | 0.0% |
| STATE STREET CORP | 1,756,814 | $4.0m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,342,014 | $3.0m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,330,205 | $3.0m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,307,171 | $3.0m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 845,431 | $1.9m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 696,599 | $1.6m | 0.0% |
| NORTHERN TRUST CORP | 682,940 | $1.5m | 0.0% |
| FRANKLIN RESOURCES INC | 678,640 | $1.5m | 0.0% |
| MORGAN STANLEY | 649,170 | $1.5m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 581,058 | $1.3m | 0.0% |
| Man Group plc | 565,593 | $1.3m | 0.0% |
| Post Resch Tallon Group Inc. | 563,478 | $1.3m | 0.9% |
| PERKINS CAPITAL MANAGEMENT INC | 526,100 | $1.2m | 0.9% |
| FMR LLC | 478,483 | $1.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 434,924 | $982,929 | 0.0% |