| BlackRock, Inc. | 22,215,127 | $64.9m | 0.0% |
| ARK Investment Management LLC | 17,932,099 | $52.4m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 8,563,424 | $25.0m | 0.0% |
| BAKER BROS. ADVISORS LP | 6,395,431 | $18.7m | 0.1% |
| D. E. Shaw & Co., Inc. | 5,485,983 | $16.0m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 5,119,019 | $15.0m | 0.0% |
| STATE STREET CORP | 4,753,962 | $13.9m | 0.0% |
| Senvest Management, LLC | 4,614,061 | $13.5m | 0.4% |
| ACADIAN ASSET MANAGEMENT LLC | 4,270,074 | $12.5m | 0.0% |
| Sumitomo Mitsui Trust Group, Inc. | 4,139,532 | $12.1m | 0.0% |
| Amova Asset Management Americas, Inc. | 4,132,534 | $12.1m | 0.2% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 4,077,187 | $11.9m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 3,484,633 | $10.2m | 0.0% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 3,472,737 | $10.1m | 1.1% |
| WASATCH ADVISORS LP | 3,383,899 | $9.9m | 0.1% |
| MACKENZIE FINANCIAL CORP | 3,002,694 | $8.8m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,768,990 | $8.1m | 0.0% |
| Soleus Capital Management, L.P. | 2,500,000 | $7.3m | 0.3% |
| IEQ CAPITAL, LLC | 2,406,330 | $7.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,317,802 | $6.8m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 1,878,275 | $5.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,733,553 | $5.1m | 0.0% |
| NORTHERN TRUST CORP | 1,697,977 | $5.0m | 0.0% |
| ALGERT GLOBAL LLC | 1,491,119 | $4.4m | 0.1% |
| VANGUARD FIDUCIARY TRUST CO | 1,427,346 | $4.2m | 0.0% |