| Timothy G. Youngquist 2020 Irrevocable Trust | 13,050,623 | $18.3m | 3.6% |
| BlackRock, Inc. | 12,003,316 | $16.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 5,949,490 | $8.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,685,567 | $5.2m | 0.0% |
| SAMSARA BIOCAPITAL, LLC | 3,428,571 | $4.8m | 0.4% |
| Kohlberg Kravis Roberts & Co. L.P. | 3,036,076 | $4.2m | 0.1% |
| STATE STREET CORP | 2,382,305 | $3.3m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,259,412 | $3.2m | 0.0% |
| CM Management, LLC | 2,100,000 | $2.9m | 1.9% |
| C WorldWide Group Holding A/S | 1,928,464 | $2.7m | 0.1% |
| Alyeska Investment Group, L.P. | 1,733,234 | $2.4m | 0.0% |
| Hudson Bay Capital Management LP | 1,693,000 | $2.4m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 1,330,201 | $1.9m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,228,069 | $1.7m | 0.0% |
| PANAGORA ASSET MANAGEMENT INC | 1,137,325 | $1.6m | 0.0% |
| NORTHERN TRUST CORP | 1,129,470 | $1.6m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 1,015,991 | $1.4m | 0.0% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 899,999 | $1.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 883,454 | $1.2m | 0.0% |
| UBS Group AG | 760,358 | $1.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 602,075 | $842,905 | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 563,056 | $788,278 | 0.0% |
| STRS OHIO | 395,600 | $553,840 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 391,000 | $547,400 | 0.0% |
| GSA CAPITAL PARTNERS LLP | 379,355 | $531,000 | 0.0% |