| Nextech Invest Ltd. | 7,419,355 | $4.1m | 0.2% |
| Deep Track Capital, LP | 7,419,355 | $4.1m | 0.1% |
| Soleus Capital Management, L.P. | 7,063,141 | $3.9m | 0.1% |
| BlackRock, Inc. | 6,169,250 | $3.4m | 0.0% |
| Avidity Partners Management LP | 4,998,267 | $2.8m | 0.4% |
| FRANKLIN RESOURCES INC | 3,803,338 | $2.1m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,432,052 | $1.9m | 0.0% |
| Octagon Capital Advisors LP | 3,050,000 | $1.7m | 0.2% |
| Blue Owl Capital Holdings LP | 2,934,015 | $1.6m | 0.2% |
| TCG Crossover Management, LLC | 2,682,696 | $1.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,830,309 | $1.0m | 0.0% |
| STATE STREET CORP | 1,413,428 | $782,898 | 0.0% |
| MPM BIOIMPACT LLC | 1,299,046 | $719,542 | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,041,399 | $576,831 | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,010,904 | $559,000 | 0.0% |
| ADAR1 Capital Management, LLC | 750,969 | $415,962 | 0.0% |
| JANE STREET GROUP, LLC | 645,209 | $357,382 | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 638,878 | $353,938 | 0.0% |
| NORTHERN TRUST CORP | 615,576 | $340,967 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 433,888 | $240,374 | 0.0% |
| MARSHALL WACE, LLP | 384,528 | $211,490 | 0.0% |
| XTX Topco Ltd | 294,301 | $163,013 | 0.0% |
| Qube Research & Technologies Ltd | 257,068 | $142,390 | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 227,850 | $126,206 | 0.0% |
| Pathstone Holdings, LLC | 214,875 | $119,019 | 0.0% |