| RA CAPITAL MANAGEMENT, L.P. | 7,808,627 | $286.8m | 2.5% |
| NOVO HOLDINGS A/S | 4,180,550 | $153.6m | 8.9% |
| FMR LLC | 3,697,837 | $135.8m | 0.0% |
| Capital International Investors | 3,603,876 | $132.4m | 0.0% |
| Deep Track Capital, LP | 3,602,093 | $132.3m | 1.9% |
| Siren, L.L.C. | 2,086,834 | $76.6m | 1.6% |
| Avoro Capital Advisors LLC | 1,925,150 | $70.7m | 0.6% |
| Bain Capital Life Sciences Investors, LLC | 1,650,000 | $60.6m | 3.6% |
| JPMORGAN CHASE & CO | 1,152,420 | $42.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 780,758 | $28.7m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 746,040 | $27.4m | 0.0% |
| Driehaus Capital Management LLC | 715,791 | $26.3m | 0.2% |
| Rock Springs Capital Management LP | 575,432 | $21.1m | 1.0% |
| Bellevue Group AG | 550,000 | $20.2m | 0.4% |
| CITADEL ADVISORS LLC | 523,450 | $19.2m | 0.0% |
| BlackRock, Inc. | 283,833 | $10.4m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 275,000 | $10.1m | 0.1% |
| ExodusPoint Capital Management, LP | 218,287 | $8.0m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 211,798 | $7.8m | 0.0% |
| BRAIDWELL LP | 160,000 | $5.9m | 0.2% |
| MARSHALL WACE, LLP | 154,674 | $5.7m | 0.0% |
| Woodline Partners LP | 150,040 | $5.5m | 0.0% |
| Affinity Asset Advisors, LLC | 138,030 | $5.1m | 0.2% |
| Ensign Peak Advisors, Inc | 115,394 | $4.2m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 112,499 | $4.1m | 0.0% |