| FMR LLC | 25,681,174 | $993.9m | 0.0% |
| BlackRock, Inc. | 17,352,646 | $671.5m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 8,072,411 | $312.4m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 7,412,330 | $286.9m | 0.0% |
| STATE STREET CORP | 6,964,919 | $269.5m | 0.0% |
| Jupiter Topco LLC | 6,624,848 | $256.4m | 0.1% |
| Fairmount Funds Management LLC | 5,503,418 | $213.0m | 14.1% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 5,006,104 | $193.7m | 2.0% |
| TCG Crossover Management, LLC | 4,854,436 | $187.9m | 4.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,652,727 | $180.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 4,508,998 | $174.5m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 4,343,977 | $168.1m | 0.0% |
| Kynam Capital Management, LP | 3,667,097 | $141.9m | 7.8% |
| LORD, ABBETT & CO. LLC | 3,431,030 | $132.8m | 0.4% |
| Polar Capital Holdings Plc | 3,232,905 | $125.1m | 0.3% |
| Commodore Capital LP | 3,050,000 | $118.0m | 7.0% |
| Assenagon Asset Management S.A. | 2,883,512 | $111.6m | 0.1% |
| Invesco Ltd. | 2,609,141 | $101.0m | 0.0% |
| Woodline Partners LP | 2,603,162 | $100.7m | 0.3% |
| Pictet Asset Management Holding SA | 2,393,515 | $92.6m | 0.1% |
| Octagon Capital Advisors LP | 2,350,000 | $90.9m | 8.2% |
| RTW INVESTMENTS, LP | 2,309,021 | $89.4m | 0.8% |
| GOLDMAN SACHS GROUP INC | 2,288,633 | $88.6m | 0.0% |
| Candriam S.C.A. | 2,088,369 | $80.7m | 0.4% |
| Deep Track Capital, LP | 2,000,000 | $77.4m | 1.1% |