| Cormorant Asset Management, LP | 2,344,971 | $22.0m | 1.1% |
| ORBIMED ADVISORS LLC | 1,737,287 | $16.3m | 0.3% |
| BlackRock, Inc. | 1,331,135 | $12.5m | 0.0% |
| Aberdeen Group plc | 1,321,750 | $12.4m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 760,940 | $7.1m | 0.0% |
| Jones Hill Capital LP | 653,572 | $6.1m | 1.3% |
| Prosight Management, LP | 650,000 | $6.1m | 1.1% |
| Stonepine Capital Management, LLC | 425,000 | $4.0m | 1.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 423,374 | $4.0m | 0.0% |
| ADAR1 Capital Management, LLC | 421,787 | $4.0m | 0.2% |
| DIADEMA PARTNERS LP | 301,264 | $2.8m | 0.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 293,203 | $2.8m | 0.0% |
| STATE STREET CORP | 254,672 | $2.4m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 190,214 | $1.8m | 0.0% |
| Exome Asset Management LLC | 184,914 | $1.7m | 1.1% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 151,640 | $1.4m | 0.0% |
| JANE STREET GROUP, LLC | 139,133 | $1.3m | 0.0% |
| NORTHERN TRUST CORP | 124,906 | $1.2m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 112,397 | $1.1m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 111,302 | $1.0m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 110,822 | $1.0m | 0.0% |
| DAFNA Capital Management LLC | 107,773 | $1.0m | 0.2% |
| CITADEL ADVISORS LLC | 92,154 | $864,405 | 0.0% |
| Advisory Services Network, LLC | 89,951 | $843,740 | 0.0% |
| CANTOR FITZGERALD, L. P. | 80,196 | $752,234 | 0.0% |