| MPM BIOIMPACT LLC | 3,666,284 | $60.1m | 3.7% |
| Siren, L.L.C. | 1,857,362 | $30.5m | 0.6% |
| Vivo Capital, LLC | 1,844,758 | $30.3m | 2.8% |
| PERCEPTIVE ADVISORS LLC | 1,653,350 | $27.1m | 0.4% |
| BAKER BROS. ADVISORS LP | 1,461,425 | $24.0m | 0.1% |
| Artisan Partners Limited Partnership | 1,372,851 | $22.5m | 0.0% |
| UBS Group AG | 1,313,439 | $21.5m | 0.0% |
| MORGAN STANLEY | 954,908 | $15.7m | 0.0% |
| Logos Global Management LP | 915,000 | $15.0m | 0.6% |
| Patient Square Capital LP | 909,474 | $14.9m | 2.3% |
| Octagon Capital Advisors LP | 574,200 | $9.4m | 0.8% |
| ADAR1 Capital Management, LLC | 528,295 | $8.7m | 0.4% |
| Redmile Group, LLC | 410,440 | $6.7m | 0.5% |
| Duquesne Family Office LLC | 383,363 | $6.3m | 0.1% |
| AMERIPRISE FINANCIAL INC | 378,497 | $6.2m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 267,783 | $4.4m | 0.0% |
| Elmind Capital, LP | 265,000 | $4.3m | 1.1% |
| JANE STREET GROUP, LLC | 223,915 | $3.7m | 0.0% |
| Ishara Investments LP | 184,500 | $3.0m | 2.2% |
| Yiheng Capital Management, L.P. | 170,142 | $2.8m | 1.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 163,401 | $2.7m | 0.0% |
| GREAT POINT PARTNERS LLC | 156,906 | $2.6m | 0.5% |
| HRT FINANCIAL LP | 151,197 | $2.5m | 0.0% |
| NEW YORK STATE COMMON RETIREMENT FUND | 119,335 | $2.0m | 0.0% |
| ENVESTNET ASSET MANAGEMENT INC | 113,823 | $1.9m | 0.0% |