| T. Rowe Price Investment Management, Inc. | 16,178,963 | $416.1m | 0.3% |
| BlackRock, Inc. | 14,026,413 | $360.8m | 0.0% |
| BAILLIE GIFFORD & CO | 11,960,230 | $307.6m | 0.3% |
| STATE STREET CORP | 7,049,304 | $181.3m | 0.0% |
| Temasek Holdings (Private) Ltd | 7,012,974 | $180.4m | 0.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 6,477,057 | $166.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,275,729 | $161.4m | 0.0% |
| FMR LLC | 4,535,836 | $116.7m | 0.0% |
| GOLDMAN SACHS GROUP INC | 4,155,895 | $106.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,973,342 | $102.2m | 0.0% |
| Holocene Advisors, LP | 3,905,225 | $100.4m | 0.2% |
| BAKER BROS. ADVISORS LP | 3,734,336 | $96.0m | 0.5% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 3,161,972 | $81.3m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,136,149 | $80.7m | 0.0% |
| UBS Group AG | 3,120,592 | $80.3m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 2,860,604 | $73.6m | 0.0% |
| NORGES BANK | 2,824,746 | $72.7m | 0.0% |
| Pictet Asset Management Holding SA | 2,791,206 | $71.9m | 0.1% |
| Capital Research Global Investors | 2,565,817 | $66.0m | 0.0% |
| Fisher Asset Management, LLC | 2,414,162 | $62.1m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 2,984,807 | $57.3m | 0.0% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 2,208,263 | $56.8m | 0.1% |
| Casdin Capital, LLC | 2,045,000 | $52.6m | 2.6% |
| Crestline Management, L.P. | 1,910,732 | $49.1m | 91.9% |
| PRINCIPAL FINANCIAL GROUP INC | 1,420,083 | $36.5m | 0.0% |