| TCG Crossover Management, LLC | 11,111,111 | $36.0m | 0.9% |
| BlackRock, Inc. | 10,589,990 | $34.3m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 8,889,000 | $28.8m | 0.3% |
| Commodore Capital LP | 8,889,000 | $28.8m | 1.7% |
| ADAR1 Capital Management, LLC | 8,889,000 | $28.8m | 1.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,141,336 | $19.9m | 0.0% |
| Paradigm Biocapital Advisors LP | 5,586,625 | $18.1m | 0.3% |
| Opaleye Management Inc. | 3,861,930 | $12.5m | 1.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,598,339 | $11.7m | 0.0% |
| Woodline Partners LP | 3,555,497 | $11.5m | 0.0% |
| Vivo Capital, LLC | 3,555,250 | $11.5m | 1.1% |
| GordonMD Global Investments LP | 3,127,000 | $10.1m | 4.9% |
| GOLDMAN SACHS GROUP INC | 2,614,036 | $8.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,569,072 | $8.3m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 2,468,919 | $8.0m | 0.0% |
| Logos Global Management LP | 2,222,000 | $7.2m | 0.3% |
| STATE STREET CORP | 2,191,803 | $7.1m | 0.0% |
| MARSHALL WACE, LLP | 2,037,287 | $6.6m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,901,002 | $6.2m | 0.0% |
| JPMORGAN CHASE & CO | 1,862,494 | $6.0m | 0.0% |
| Nantahala Capital Management, LLC | 1,705,400 | $5.5m | 0.1% |
| AQR CAPITAL MANAGEMENT LLC | 1,572,242 | $5.1m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,332,976 | $4.3m | 0.0% |
| Seven Fleet Capital Management LP | 1,330,500 | $4.3m | 0.7% |
| RAYMOND JAMES FINANCIAL INC | 1,318,947 | $4.3m | 0.0% |