| BVF INC/IL | 6,293,282 | $24.8m | 0.6% |
| BlackRock, Inc. | 5,123,842 | $20.2m | 0.0% |
| Defilade Capital Management, L.P. | 3,525,338 | $13.9m | 1.9% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,417,223 | $13.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,510,308 | $9.9m | 0.0% |
| Ensign Peak Advisors, Inc | 2,101,224 | $8.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,956,601 | $7.7m | 0.0% |
| Catalio Capital Management, LP | 1,695,071 | $6.7m | 1.3% |
| STATE STREET CORP | 1,621,969 | $6.4m | 0.0% |
| Zimmer Partners, LP | 1,596,599 | $6.3m | 0.1% |
| SPHERA FUNDS MANAGEMENT LTD. | 1,191,187 | $4.7m | 0.6% |
| AWM Investment Company, Inc. | 1,100,000 | $4.3m | 0.4% |
| UBS Group AG | 1,048,245 | $4.1m | 0.0% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,039,275 | $4.1m | 0.4% |
| MILLENNIUM MANAGEMENT LLC | 979,712 | $3.9m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 883,097 | $3.5m | 0.0% |
| ADAR1 Capital Management, LLC | 647,812 | $2.6m | 0.1% |
| 22NW, LP | 636,364 | $2.5m | 2.4% |
| NORTHERN TRUST CORP | 616,399 | $2.4m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 581,028 | $2.3m | 0.0% |
| CM Management, LLC | 575,000 | $2.3m | 1.4% |
| Blue Owl Capital Holdings LP | 566,509 | $2.2m | 0.3% |
| DIMENSIONAL FUND ADVISORS LP | 538,738 | $2.1m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 533,365 | $2.1m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 528,963 | $2.1m | 0.0% |