| Beutel, Goodman & Co Ltd. | 3,627,864 | $23.8m | 0.2% |
| Affinity Asset Advisors, LLC | 1,650,000 | $10.9m | 0.5% |
| Balyasny Asset Management L.P. | 1,350,015 | $8.9m | 0.0% |
| Vivo Capital, LLC | 1,350,000 | $8.9m | 0.8% |
| SCOTIA CAPITAL INC. | 1,343,726 | $8.8m | 0.0% |
| PFM Health Sciences, LP | 1,210,661 | $8.0m | 0.7% |
| GREAT POINT PARTNERS LLC | 1,200,000 | $7.9m | 1.5% |
| Jupiter Topco LLC | 1,046,000 | $6.9m | 0.0% |
| Rubric Capital Management LP | 867,424 | $5.7m | 0.1% |
| Ikarian Capital, LLC | 809,741 | $5.4m | 0.6% |
| Woodline Partners LP | 746,864 | $4.9m | 0.0% |
| Point72 Asset Management, L.P. | 730,284 | $4.8m | 0.0% |
| AMERIPRISE FINANCIAL INC | 711,024 | $4.7m | 0.0% |
| Redmile Group, LLC | 611,400 | $4.0m | 0.3% |
| Seven Fleet Capital Management LP | 610,785 | $4.0m | 0.7% |
| UBS Group AG | 519,211 | $3.4m | 0.0% |
| CITADEL ADVISORS LLC | 502,011 | $3.3m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 441,586 | $2.9m | 0.0% |
| Alyeska Investment Group, L.P. | 375,000 | $2.5m | 0.0% |
| PICTON MAHONEY ASSET MANAGEMENT | 360,878 | $2.4m | 0.0% |
| Velan Capital Investment Management LP | 352,000 | $2.3m | 1.4% |
| JANE STREET GROUP, LLC | 329,053 | $2.2m | 0.0% |
| Aisling Capital Management LP | 325,000 | $2.1m | 0.5% |
| SummitTX Capital, L.P. | 318,784 | $2.1m | 0.1% |
| ROYAL BANK OF CANADA | 311,435 | $2.1m | 0.0% |