| Jupiter Topco LLC | 6,494,571 | $20.7m | 0.0% |
| Decheng Capital LLC | 4,447,308 | $14.2m | 1.9% |
| Affinity Asset Advisors, LLC | 4,100,000 | $13.1m | 0.6% |
| ADAR1 Capital Management, LLC | 3,758,569 | $12.0m | 0.5% |
| Aberdeen Group plc | 3,631,659 | $11.6m | 0.0% |
| Woodline Partners LP | 3,500,901 | $11.2m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 3,096,336 | $9.9m | 0.1% |
| STEMPOINT CAPITAL LP | 2,016,607 | $6.5m | 1.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,822,812 | $5.8m | 0.0% |
| Eversept Partners, LP | 1,520,824 | $4.9m | 0.3% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,390,253 | $4.4m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 637,617 | $2.0m | 0.0% |
| Exome Asset Management LLC | 552,956 | $1.8m | 1.1% |
| DG Capital Management, LLC | 463,396 | $1.5m | 0.3% |
| DIADEMA PARTNERS LP | 400,282 | $1.3m | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 381,175 | $1.2m | 0.0% |
| Balyasny Asset Management L.P. | 344,409 | $1.1m | 0.0% |
| TUDOR INVESTMENT CORP ET AL | 320,100 | $1.0m | 0.0% |
| Ikarian Capital, LLC | 303,555 | $971,376 | 0.1% |
| BlackRock, Inc. | 285,409 | $913,308 | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 284,330 | $909,856 | 0.0% |
| CANTOR FITZGERALD, L. P. | 218,124 | $697,996 | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 206,853 | $661,930 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 190,810 | $610,592 | 0.0% |
| STATE STREET CORP | 174,060 | $556,992 | 0.0% |