| EQT Fund Management S.a r.l. | 5,288,313 | $70.3m | 8.1% |
| RA CAPITAL MANAGEMENT, L.P. | 3,494,638 | $46.4m | 0.4% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,940,939 | $25.8m | 0.0% |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,926,943 | $25.6m | 8.3% |
| JPMORGAN CHASE & CO | 1,553,132 | $23.4m | 0.0% |
| RTW INVESTMENTS, LP | 1,502,235 | $20.0m | 0.2% |
| Nan Fung Group Holdings Ltd | 1,441,032 | $19.2m | 14.6% |
| Point72 Asset Management, L.P. | 1,435,049 | $19.1m | 0.0% |
| ANDERA PARTNERS | 1,391,990 | $18.5m | 9.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,209,129 | $16.1m | 0.2% |
| Vestal Point Capital, LP | 1,000,000 | $13.3m | 0.3% |
| Jupiter Topco LLC | 896,700 | $11.9m | 0.0% |
| BlackRock, Inc. | 886,538 | $11.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 881,895 | $11.7m | 0.0% |
| BAKER BROS. ADVISORS LP | 847,390 | $11.3m | 0.1% |
| Defilade Capital Management, L.P. | 793,145 | $10.5m | 1.4% |
| AMERICAN CENTURY COMPANIES INC | 755,018 | $10.0m | 0.0% |
| Alyeska Investment Group, L.P. | 704,425 | $9.4m | 0.0% |
| Balyasny Asset Management L.P. | 457,015 | $6.1m | 0.0% |
| Velan Capital Investment Management LP | 451,255 | $6.0m | 3.7% |
| UBS Group AG | 413,553 | $5.5m | 0.0% |
| FEDERATED HERMES, INC. | 325,000 | $4.3m | 0.0% |
| GREAT POINT PARTNERS LLC | 325,000 | $4.3m | 0.8% |
| Freestone Grove Partners LP | 306,328 | $4.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 301,759 | $4.0m | 0.0% |