| MONTANOVA CAPITAL, LLC | 2,020,103 | $50.5m | 0.9% |
| Avoro Capital Advisors LLC | 1,444,039 | $36.1m | 0.3% |
| BAKER BROS. ADVISORS LP | 1,286,411 | $32.2m | 0.2% |
| Balyasny Asset Management L.P. | 1,042,198 | $26.1m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 722,020 | $18.1m | 0.2% |
| Vivo Capital, LLC | 722,020 | $18.1m | 1.6% |
| Logos Global Management LP | 722,020 | $18.1m | 0.8% |
| Fairmount Funds Management LLC | 722,020 | $18.1m | 1.2% |
| Caligan Partners LP | 629,467 | $15.7m | 0.7% |
| B Group, Inc. | 610,169 | $15.3m | 7.2% |
| Trails Edge Capital Partners, LP | 515,335 | $12.9m | 2.0% |
| FRANKLIN RESOURCES INC | 494,516 | $12.4m | 0.0% |
| Octagon Capital Advisors LP | 361,010 | $9.0m | 0.8% |
| ADAR1 Capital Management, LLC | 361,010 | $9.0m | 0.4% |
| Cormorant Asset Management, LP | 1,028,242 | $7.7m | 0.4% |
| MARSHALL WACE, LLP | 206,508 | $5.2m | 0.0% |
| Boxer Capital Management, LLC | 180,505 | $4.5m | 0.3% |
| Patient Square Capital LP | 175,050 | $4.4m | 0.7% |
| Alyeska Investment Group, L.P. | 144,404 | $3.6m | 0.0% |
| Affinity Asset Advisors, LLC | 144,404 | $3.6m | 0.2% |
| BOOTHBAY FUND MANAGEMENT, LLC | 133,643 | $3.3m | 0.0% |
| AWM Investment Company, Inc. | 111,343 | $2.8m | 0.2% |
| Richmond Investment Services, LLC | 79,731 | $2.0m | 0.6% |
| Ikarian Capital, LLC | 35,386 | $884,650 | 0.1% |
| UBS Group AG | 21,541 | $538,525 | 0.0% |