| Affinity Asset Advisors, LLC | 4,007,881 | $7.0m | 0.3% |
| Cormorant Asset Management, LP | 3,570,000 | $6.2m | 0.3% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 3,520,490 | $6.2m | 0.6% |
| Vestal Point Capital, LP | 2,600,000 | $4.5m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,098,151 | $3.7m | 0.0% |
| Frazier Life Sciences Management, L.P. | 1,953,467 | $3.4m | 0.1% |
| Ensign Peak Advisors, Inc | 1,832,457 | $3.2m | 0.0% |
| Woodline Partners LP | 1,776,547 | $3.1m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,651,473 | $2.9m | 0.0% |
| CITADEL ADVISORS LLC | 1,384,029 | $2.4m | 0.0% |
| Balyasny Asset Management L.P. | 1,170,893 | $2.0m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,121,492 | $2.0m | 0.0% |
| Ikarian Capital, LLC | 957,062 | $1.7m | 0.2% |
| Sio Capital Management, LLC | 904,268 | $1.6m | 0.3% |
| MARSHALL WACE, LLP | 904,132 | $1.6m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 500,816 | $876,650 | 0.0% |
| Walleye Capital LLC | 500,375 | $875,656 | 0.0% |
| Squarepoint Ops LLC | 498,872 | $873,026 | 0.0% |
| NOESIS CAPITAL MANGEMENT CORP | 405,000 | $708,750 | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 400,667 | $701,167 | 0.0% |
| Ally Bridge Group (NY) LLC | 390,147 | $682,757 | 0.6% |
| ADAR1 Capital Management, LLC | 375,531 | $657,179 | 0.0% |
| Verdad Advisers, LP | 298,927 | $523,122 | 0.5% |
| VANGUARD FIDUCIARY TRUST CO | 286,875 | $502,031 | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 254,412 | $445,221 | 0.0% |