| Sands Capital Alternatives, LLC | 13,018,965 | $26.4m | 4.3% |
| Soleus Capital Management, L.P. | 10,875,000 | $22.1m | 0.8% |
| Trails Edge Capital Partners, LP | 9,051,318 | $18.4m | 2.9% |
| Fairmount Funds Management LLC | 8,625,000 | $17.5m | 1.2% |
| BlackRock, Inc. | 7,768,057 | $15.8m | 0.0% |
| Kalehua Capital Management LLC | 7,643,780 | $15.5m | 4.9% |
| ADAR1 Capital Management, LLC | 7,387,205 | $15.0m | 0.7% |
| Blackstone Inc. | 5,938,276 | $12.1m | 0.0% |
| Siren, L.L.C. | 5,850,000 | $11.9m | 0.2% |
| Nantahala Capital Management, LLC | 5,403,726 | $11.0m | 0.2% |
| Commodore Capital LP | 5,397,488 | $11.0m | 0.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,935,354 | $10.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 4,028,102 | $8.2m | 0.0% |
| Saturn V Capital Management LP | 3,869,056 | $7.9m | 1.1% |
| Spruce Street Capital LP | 3,581,603 | $7.3m | 1.4% |
| Squadron Capital Management LLC | 3,000,000 | $6.1m | 1.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,607,129 | $5.3m | 0.0% |
| STATE STREET CORP | 1,909,101 | $3.9m | 0.0% |
| SummitTX Capital, L.P. | 1,780,262 | $3.6m | 0.1% |
| Integral Health Asset Management, LLC | 1,350,000 | $2.7m | 0.1% |
| NORTHERN TRUST CORP | 878,585 | $1.8m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 809,490 | $1.6m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 806,264 | $1.6m | 0.0% |
| SPHERA FUNDS MANAGEMENT LTD. | 649,309 | $1.3m | 0.2% |
| VANGUARD FIDUCIARY TRUST CO | 607,260 | $1.2m | 0.0% |