| WELLINGTON MANAGEMENT GROUP LLP | 5,721,945 | $181.7m | 0.0% |
| RTW INVESTMENTS, LP | 4,869,798 | $154.6m | 1.3% |
| FMR LLC | 4,307,246 | $136.8m | 0.0% |
| PRIMECAP MANAGEMENT CO/CA/ | 3,638,241 | $115.5m | 0.1% |
| Bellevue Group AG | 2,788,245 | $88.5m | 1.9% |
| TANG CAPITAL MANAGEMENT LLC | 2,649,368 | $84.1m | 3.8% |
| Vestal Point Capital, LP | 1,800,000 | $57.1m | 1.3% |
| TWO SIGMA INVESTMENTS, LP | 1,648,983 | $52.4m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,597,037 | $50.7m | 0.0% |
| ARMISTICE CAPITAL, LLC | 1,428,000 | $45.3m | 0.6% |
| Caligan Partners LP | 1,381,317 | $43.9m | 2.1% |
| Kynam Capital Management, LP | 1,375,000 | $43.7m | 2.4% |
| BVF INC/IL | 1,294,463 | $41.1m | 1.1% |
| ACADIAN ASSET MANAGEMENT LLC | 1,209,894 | $38.4m | 0.0% |
| Trails Edge Capital Partners, LP | 1,063,234 | $33.8m | 5.4% |
| BlackRock, Inc. | 1,004,598 | $31.9m | 0.0% |
| Point72 Asset Management, L.P. | 990,280 | $31.4m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 831,068 | $26.4m | 0.0% |
| Jupiter Topco LLC | 709,022 | $22.5m | 0.0% |
| CANTOR FITZGERALD, L. P. | 680,200 | $21.6m | 0.1% |
| Logos Global Management LP | 600,000 | $19.1m | 0.8% |
| MARSHALL WACE, LLP | 590,941 | $18.8m | 0.0% |
| Hudson Bay Capital Management LP | 590,000 | $18.7m | 0.1% |
| CITADEL ADVISORS LLC | 566,761 | $18.0m | 0.0% |
| BRAIDWELL LP | 521,327 | $16.6m | 0.6% |