| BAKER BROS. ADVISORS LP | 30,762,330 | $3.5bn | 17.5% |
| BlackRock, Inc. | 18,032,718 | $2.0bn | 0.0% |
| Dodge & Cox | 11,957,326 | $1.4bn | 0.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 11,024,289 | $1.2bn | 0.0% |
| STATE STREET CORP | 9,722,336 | $1.1bn | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 7,791,091 | $883.2m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 5,320,901 | $603.2m | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 4,750,735 | $536.5m | 0.0% |
| LSV ASSET MANAGEMENT | 4,123,759 | $467.5m | 0.8% |
| Invesco Ltd. | 4,080,461 | $462.6m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 3,575,521 | $405.3m | 0.1% |
| RENAISSANCE TECHNOLOGIES LLC | 3,512,132 | $398.1m | 0.5% |
| MORGAN STANLEY | 2,948,364 | $334.2m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,744,958 | $311.2m | 0.1% |
| Robeco Institutional Asset Management B.V. | 2,441,735 | $276.8m | 0.3% |
| GOLDMAN SACHS GROUP INC | 2,305,782 | $261.4m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 2,280,803 | $258.6m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,003,559 | $227.1m | 0.2% |
| NORTHERN TRUST CORP | 1,761,966 | $199.7m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,692,439 | $191.9m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,664,999 | $188.7m | 0.2% |
| Legal & General Group Plc | 1,605,980 | $182.1m | 0.0% |
| FIRST TRUST ADVISORS LP | 1,587,996 | $180.0m | 0.1% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,508,720 | $171.0m | 0.0% |
| VICTORY CAPITAL MANAGEMENT INC | 1,480,342 | $167.8m | 0.1% |