| Nantahala Capital Management, LLC | 6,122,718 | $25.2m | 0.4% |
| Caligan Partners LP | 6,077,084 | $25.0m | 1.2% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 6,029,775 | $24.8m | 0.0% |
| BIOS Capital Management, LP | 3,683,429 | $15.1m | 36.3% |
| BlackRock, Inc. | 3,116,487 | $12.8m | 0.0% |
| Balyasny Asset Management L.P. | 3,087,866 | $12.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,958,683 | $12.2m | 0.0% |
| Boxer Capital Management, LLC | 2,815,000 | $11.6m | 0.9% |
| Trails Edge Capital Partners, LP | 2,743,658 | $11.3m | 1.8% |
| MILLENNIUM MANAGEMENT LLC | 2,302,101 | $9.5m | 0.0% |
| GREAT POINT PARTNERS LLC | 1,970,187 | $8.1m | 1.5% |
| MARSHALL WACE, LLP | 1,945,609 | $8.0m | 0.0% |
| ADAR1 Capital Management, LLC | 1,783,781 | $7.3m | 0.3% |
| GOLDMAN SACHS GROUP INC | 1,527,229 | $6.3m | 0.0% |
| Woodline Partners LP | 1,434,713 | $5.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,367,712 | $5.6m | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 1,189,515 | $4.9m | 0.1% |
| Opaleye Management Inc. | 1,125,000 | $4.6m | 0.4% |
| SummitTX Capital, L.P. | 1,007,351 | $4.1m | 0.1% |
| STATE STREET CORP | 790,136 | $3.2m | 0.0% |
| Bleichroeder LP | 736,842 | $3.0m | 0.5% |
| UBS Group AG | 683,895 | $2.8m | 0.0% |
| CITADEL ADVISORS LLC | 665,662 | $2.7m | 0.0% |
| MORGAN STANLEY | 464,900 | $1.9m | 0.0% |
| NORTHERN TRUST CORP | 442,154 | $1.8m | 0.0% |