| Caligan Partners LP | 8,163,191 | $30.9m | 1.5% |
| SAMSARA BIOCAPITAL, LLC | 6,314,805 | $23.9m | 2.0% |
| Nantahala Capital Management, LLC | 5,372,786 | $20.3m | 0.3% |
| Paradigm Biocapital Advisors LP | 4,000,000 | $15.1m | 0.3% |
| ANDERA PARTNERS | 3,633,181 | $13.7m | 6.7% |
| ADAR1 Capital Management, LLC | 3,606,656 | $13.6m | 0.6% |
| MILLENNIUM MANAGEMENT LLC | 3,512,174 | $13.3m | 0.0% |
| Trails Edge Capital Partners, LP | 2,657,997 | $10.0m | 1.6% |
| FRANKLIN RESOURCES INC | 2,642,611 | $10.0m | 0.0% |
| Squadron Capital Management LLC | 2,435,000 | $9.2m | 2.9% |
| Woodline Partners LP | 2,323,149 | $8.8m | 0.0% |
| Aberdeen Group plc | 2,307,773 | $8.7m | 0.0% |
| UBS Group AG | 2,305,192 | $8.7m | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 2,003,782 | $7.6m | 0.1% |
| Patient Square Capital LP | 1,967,171 | $7.4m | 1.2% |
| NEXTBio Capital Management LP | 1,787,984 | $6.8m | 3.1% |
| CITADEL ADVISORS LLC | 1,784,566 | $6.7m | 0.0% |
| AMERIPRISE FINANCIAL INC | 1,697,148 | $6.4m | 0.0% |
| Point72 Asset Management, L.P. | 1,683,012 | $6.4m | 0.0% |
| Integral Health Asset Management, LLC | 1,520,000 | $5.7m | 0.2% |
| Yu Fan | 1,500,000 | $5.7m | 5.3% |
| NEA Management Company, LLC | 1,462,586 | $5.5m | 0.3% |
| STEMPOINT CAPITAL LP | 1,426,320 | $5.4m | 0.9% |
| Propel Bio Management, LLC | 1,281,212 | $4.8m | 2.5% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,270,000 | $4.8m | 0.5% |