| HRTG GPE, LLC | 16,917,034 | $403.5m | 16.3% |
| FMR LLC | 8,909,066 | $212.5m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 8,200,662 | $195.6m | 2.9% |
| T. Rowe Price Investment Management, Inc. | 4,207,130 | $100.3m | 0.1% |
| Capital Research Global Investors | 3,598,942 | $85.8m | 0.0% |
| JPMORGAN CHASE & CO | 1,790,734 | $46.4m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 1,534,837 | $36.6m | 0.0% |
| Liberty Mutual Group Asset Management Inc. | 1,196,411 | $28.5m | 2.5% |
| JENNISON ASSOCIATES LLC | 903,575 | $21.6m | 0.0% |
| Paradigm Biocapital Advisors LP | 900,000 | $21.5m | 0.4% |
| Jupiter Topco LLC | 749,703 | $17.7m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 658,787 | $15.7m | 0.0% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 650,000 | $15.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 644,969 | $15.4m | 0.0% |
| Deep Track Capital, LP | 600,000 | $14.3m | 0.2% |
| Woodline Partners LP | 413,980 | $9.9m | 0.0% |
| FRANKLIN RESOURCES INC | 400,021 | $9.5m | 0.0% |
| MONTANOVA CAPITAL, LLC | 400,000 | $9.5m | 0.2% |
| Bank of New York Mellon Corp | 377,758 | $9.0m | 0.0% |
| Catalio Capital Management, LP | 312,500 | $7.5m | 1.4% |
| PRINCIPAL FINANCIAL GROUP INC | 300,000 | $7.2m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 300,000 | $7.2m | 0.1% |
| BRAIDWELL LP | 300,000 | $7.2m | 0.3% |
| UBS Group AG | 267,760 | $6.4m | 0.0% |
| PEREGRINE CAPITAL MANAGEMENT LLC | 229,776 | $5.5m | 0.2% |