| SAMSARA BIOCAPITAL, LLC | 12,881,175 | $52.4m | 4.3% |
| RTW INVESTMENTS, LP | 1,300,000 | $5.3m | 0.0% |
| Alyeska Investment Group, L.P. | 572,687 | $2.3m | 0.0% |
| Siren, L.L.C. | 435,798 | $1.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 398,712 | $1.6m | 0.0% |
| Ikarian Capital, LLC | 360,000 | $1.5m | 0.2% |
| UBS Group AG | 262,131 | $1.1m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 149,351 | $607,859 | 0.0% |
| MARSHALL WACE, LLP | 139,201 | $566,549 | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 114,037 | $464,287 | 0.0% |
| Woodline Partners LP | 100,000 | $407,000 | 0.0% |
| ADAR1 Capital Management, LLC | 100,000 | $407,000 | 0.0% |
| WHI TRUST Co LLC | 97,493 | $396,797 | 0.3% |
| RAYMOND JAMES FINANCIAL INC | 97,164 | $395,457 | 0.0% |
| CITADEL ADVISORS LLC | 95,772 | $389,792 | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 92,261 | $375,502 | 0.0% |
| Verdad Advisers, LP | 80,297 | $326,809 | 0.3% |
| MORGAN STANLEY | 72,326 | $294,367 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 66,179 | $269,349 | 0.0% |
| BlackRock, Inc. | 54,442 | $221,580 | 0.0% |
| Belpointe Asset Management LLC | 40,000 | $162,800 | 0.0% |
| Fortis Capital Advisors, LLC | 40,000 | $162,800 | 0.0% |
| Pale Fire Capital SE | 39,626 | $161,278 | 0.0% |
| Squarepoint Ops LLC | 38,775 | $157,814 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 32,500 | $132,275 | 0.0% |