| RA CAPITAL MANAGEMENT, L.P. | 1,917,354 | $18.7m | 0.2% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,521,322 | $14.9m | 0.0% |
| ACORN CAPITAL ADVISORS, LLC | 1,518,113 | $14.8m | 4.0% |
| GOLDMAN SACHS GROUP INC | 1,424,658 | $13.9m | 0.0% |
| BlackRock, Inc. | 1,418,799 | $13.9m | 0.0% |
| Kalehua Capital Management LLC | 1,371,288 | $13.4m | 4.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 958,979 | $9.4m | 0.0% |
| Catalio Capital Management, LP | 940,855 | $9.2m | 1.7% |
| Avidity Partners Management LP | 924,487 | $9.0m | 1.4% |
| T. Rowe Price Investment Management, Inc. | 786,309 | $7.7m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 695,264 | $6.8m | 0.0% |
| NEA Management Company, LLC | 576,780 | $5.6m | 0.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 531,231 | $5.2m | 0.0% |
| Ghisallo Capital Management LLC | 500,000 | $4.9m | 0.1% |
| Soleus Capital Management, L.P. | 440,000 | $4.3m | 0.1% |
| UBS Group AG | 353,545 | $3.5m | 0.0% |
| STATE STREET CORP | 325,991 | $3.2m | 0.0% |
| Affinity Asset Advisors, LLC | 312,500 | $3.1m | 0.1% |
| Brevan Howard Capital Management LP | 309,817 | $3.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 305,676 | $3.0m | 0.0% |
| Boxer Capital Management, LLC | 302,536 | $3.0m | 0.2% |
| Davidson Kempner Capital Management LP | 300,000 | $2.9m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 298,997 | $2.9m | 0.0% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 297,460 | $2.9m | 0.3% |
| Eversept Partners, LP | 276,174 | $2.7m | 0.1% |