| FMR LLC | 4,418,197 | $1.6bn | 0.1% |
| BlackRock, Inc. | 4,181,432 | $1.6bn | 0.0% |
| Avoro Capital Advisors LLC | 2,888,888 | $1.1bn | 9.6% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,574,905 | $585.3m | 0.0% |
| STATE STREET CORP | 1,351,158 | $502.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,240,567 | $461.1m | 0.0% |
| Soleus Capital Management, L.P. | 939,254 | $349.1m | 12.0% |
| Capital World Investors | 777,843 | $289.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 698,993 | $259.8m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 687,400 | $255.5m | 0.0% |
| Hood River Capital Management LLC | 663,375 | $246.6m | 1.8% |
| Redmile Group, LLC | 632,005 | $234.9m | 15.8% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 570,153 | $211.9m | 0.6% |
| Frazier Life Sciences Management, L.P. | 481,307 | $178.9m | 3.9% |
| DIMENSIONAL FUND ADVISORS LP | 476,038 | $176.9m | 0.0% |
| FIRST TRUST ADVISORS LP | 324,900 | $120.8m | 0.1% |
| Invesco Ltd. | 324,755 | $120.7m | 0.0% |
| GOLDMAN SACHS GROUP INC | 298,841 | $111.1m | 0.0% |
| NORTHERN TRUST CORP | 283,784 | $105.5m | 0.0% |
| FRANKLIN RESOURCES INC | 261,917 | $97.3m | 0.0% |
| NORGES BANK | 259,030 | $96.3m | 0.0% |
| Jupiter Topco LLC | 256,665 | $95.4m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 256,431 | $95.3m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 254,828 | $94.7m | 0.0% |
| MORGAN STANLEY | 235,491 | $87.5m | 0.0% |