| BlackRock, Inc. | 10,509,233 | $115.3m | 0.0% |
| MONTANOVA CAPITAL, LLC | 8,575,422 | $94.1m | 1.7% |
| BVF INC/IL | 8,445,769 | $92.7m | 2.4% |
| STATE STREET CORP | 5,329,208 | $58.5m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,916,164 | $43.0m | 0.0% |
| ARMISTICE CAPITAL, LLC | 3,678,000 | $40.3m | 0.5% |
| AQR CAPITAL MANAGEMENT LLC | 3,126,727 | $34.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,265,171 | $24.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,229,958 | $24.5m | 0.0% |
| ALETHEA CAPITAL MANAGEMENT, LLC | 2,167,938 | $23.8m | 9.9% |
| Prosight Management, LP | 2,021,964 | $22.2m | 3.8% |
| Deep Track Capital, LP | 1,978,565 | $21.7m | 0.3% |
| RENAISSANCE TECHNOLOGIES LLC | 1,663,765 | $18.3m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,410,275 | $15.5m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,329,941 | $14.6m | 0.0% |
| NAN FUNG TRINITY (HK) LTD | 1,174,880 | $12.9m | 1.3% |
| Qube Research & Technologies Ltd | 1,169,884 | $12.8m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,169,189 | $12.8m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,160,921 | $12.7m | 0.0% |
| MORGAN STANLEY | 1,160,310 | $12.7m | 0.0% |
| Connor, Clark & Lunn Investment Management Ltd. | 996,114 | $10.9m | 0.0% |
| UBS Group AG | 964,636 | $10.6m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 948,974 | $10.4m | 0.0% |
| NORTHERN TRUST CORP | 831,160 | $9.1m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 711,332 | $7.8m | 0.0% |